[HTML][HTML] Enzymes for detoxification of various mycotoxins: origins and mechanisms of catalytic action

I Lyagin, E Efremenko - Molecules, 2019 - mdpi.com
Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic
transformation seems to be the most promising method for detoxification of mycotoxins. This …

Bioenzymatic detoxification of mycotoxins

M Liu, X Zhang, H Luan, Y Zhang, W Xu… - Frontiers in …, 2024 - frontiersin.org
Mycotoxins are secondary metabolites produced during the growth, storage, and
transportation of crops contaminated by fungi and are physiologically toxic to humans and …

[HTML][HTML] Turning inside out: Filamentous fungal secretion and its applications in biotechnology, agriculture, and the clinic

TC Cairns, X Zheng, P Zheng, J Sun, V Meyer - Journal of Fungi, 2021 - mdpi.com
Filamentous fungi are found in virtually every marine and terrestrial habitat. Vital to this
success is their ability to secrete a diverse range of molecules, including hydrolytic enzymes …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

The toxic mechanism of gliotoxins and biosynthetic strategies for toxicity prevention

W Ye, T Liu, W Zhang, W Zhang - International Journal of Molecular …, 2021 - mdpi.com
Gliotoxin is a kind of epipolythiodioxopiperazine derived from different fungi that is
characterized by a disulfide bridge. Gliotoxins can be biosynthesized by a gli gene cluster …

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

EM Huber - ChemBioChem, 2022 - Wiley Online Library
Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

One-pot assay using a target-driven split aptamer recognition and assembly strategy for convenient and rapid detection of gliotoxin

X Zheng, Z Hu, S Gao, Z Li, J Chen, G Zhang, N Kong… - Food Chemistry, 2024 - Elsevier
An aptamer targeting gliotoxin (GTX) was optimized to increase the binding affinity by
approximately 20 times and achieve higher structural stability and targeting specificity …

Target-induced AIE effect coupled with CRISPR/Cas12a system dual-signal biosensing for the ultrasensitive detection of Gliotoxin

X Ma, Y Zhang, X Qiao, Y Yuan, Q Sheng… - Analytical …, 2023 - ACS Publications
Here, a novel rapid and ultrasensitive aptamer biosensor was designed for target-induced
activation of AIE effect and followed by the activation of Crispr Cas12a (LbCpf1)-mediated …

Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp.: Molecular and Therapeutic …

AM Traynor, KJ Sheridan, GW Jones… - Frontiers in …, 2019 - frontiersin.org
Fungal sulfur uptake is required for incorporation into the sidechains of the amino acids
cysteine and methionine, and is also essential for the biosynthesis of the antioxidant …

Production, stability and degradation of Trichoderma gliotoxin in growth medium, irrigation water and agricultural soil

R Jayalakshmi, R Oviya, K Premalatha, ST Mehetre… - Scientific Reports, 2021 - nature.com
Gliotoxin produced by Trichoderma virens is inhibitory against various phytopathogenic
fungi and bacteria. However, its stability in soil-ecosystem has not yet been well-defined …