Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

Obesity I: Overview and molecular and biochemical mechanisms

RH Lustig, D Collier, C Kassotis, TA Roepke… - Biochemical …, 2022 - Elsevier
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

J Korbecki, K Bajdak-Rusinek - Inflammation Research, 2019 - Springer
Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …

New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases

X Li, B Zhang, Y Hu, Y Zhao - Frontiers in Pharmacology, 2021 - frontiersin.org
The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

CD36 tango in cancer: signaling pathways and functions

J Wang, Y Li - Theranostics, 2019 - pmc.ncbi.nlm.nih.gov
CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

CD36 favours fat sensing and transport to govern lipid metabolism

Y Li, X Huang, G Yang, K Xu, Y Yin, G Brecchia… - Progress in lipid …, 2022 - Elsevier
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

L Hodson, PJ Gunn - Nature Reviews Endocrinology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …

Bile acid signaling in metabolic disease and drug therapy

T Li, JYL Chiang - Pharmacological reviews, 2014 - Elsevier
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

[HTML][HTML] Alcohol effects on hepatic lipid metabolism

S Jeon, R Carr - Journal of lipid research, 2020 - Elsevier
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …