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Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
Obesity I: Overview and molecular and biochemical mechanisms
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …
has increased globally since the 1970s, and the number of obese and overweight people is …
The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms
J Korbecki, K Bajdak-Rusinek - Inflammation Research, 2019 - Springer
Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …
New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases
X Li, B Zhang, Y Hu, Y Zhao - Frontiers in Pharmacology, 2021 - frontiersin.org
The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …
CD36 tango in cancer: signaling pathways and functions
J Wang, Y Li - Theranostics, 2019 - pmc.ncbi.nlm.nih.gov
CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
CD36 favours fat sensing and transport to govern lipid metabolism
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …
The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state
L Hodson, PJ Gunn - Nature Reviews Endocrinology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …
Bile acid signaling in metabolic disease and drug therapy
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …
[HTML][HTML] Alcohol effects on hepatic lipid metabolism
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …