New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature Reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Marshalling the potential of Auger electron radiopharmaceutical therapy

J Bolcaen, MA Gizawy, SYA Terry… - Journal of Nuclear …, 2023 - jnm.snmjournals.org
Auger electron (AE) radiopharmaceutical therapy (RPT) may have the same therapeutic
efficacy as α-particles for oncologic small disease, with lower risks of normal-tissue toxicity …

Applications of radiocomplexes with thiosemicarbazones and bis (thiosemicarbazones) in diagnostic and therapeutic nuclear medicine

GL Parrilha, RG dos Santos, H Beraldo - Coordination Chemistry Reviews, 2022 - Elsevier
Metallic radionuclides possess a variety of half-lives, emission types, energies, and
branching ratios, making it possible to apply them as diagnostic and/or therapeutic agents …

[HTML][HTML] The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker

HA Holik, FM Ibrahim, AA Elaine, BD Putra, A Achmad… - Molecules, 2022 - mdpi.com
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …

[HTML][HTML] Radiometals in imaging and therapy: highlighting two decades of research

S Sharma, MK Pandey - Pharmaceuticals, 2023 - mdpi.com
The present article highlights the important progress made in the last two decades in the
fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based …

Organic coordination nanoparticles for phototheranostics

H Ren, J Li, JF Lovell, Y Zhang - Coordination Chemistry Reviews, 2024 - Elsevier
Nanomedicines can integrate multiple functionalities to improve the efficacy of disease
treatment with reduced off-target toxicity. However, challenges such as tedious synthesis …

Evaluation of 134Ce/134La as a PET imaging theranostic pair for 225Ac α-radiotherapeutics

KN Bobba, AP Bidkar, N Meher, C Fong… - Journal of Nuclear …, 2023 - jnm.snmjournals.org
225Ac-targeted α-radiotherapy is a promising approach to treating malignancies, including
prostate cancer. However, α-emitting isotopes are difficult to image because of low …

Radioimmunotherapy in oncology: overview of the last decade clinical trials

A Rondon, J Rouanet, F Degoul - Cancers, 2021 - mdpi.com
Simple Summary Monoclonal antibody-bearing radionuclides have been under clinical
investigation over the last two decades for their use in theranostic (diagnostic and …

An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics

V Benfante, A Stefano, M Ali, R Laudicella, W Arancio… - Diagnostics, 2023 - mdpi.com
Radionuclides are unstable isotopes that mainly emit alpha (α), beta (β) or gamma (γ)
radiation through radiation decay. Therefore, they are used in the biomedical field to label …

Bispidine chelators for radiopharmaceutical applications with lanthanide, actinide, and main group metal ions

I Kopp, P Cieslik, K Anger, T Josephy… - Inorganic …, 2023 - ACS Publications
Octadentate and specifically nonadentate ligands with a bispidine scaffold (3, 7-diazabicyclo
[3.3. 1] nonane) are known to be efficiently coordinated to a range of metal ions of interest in …