Regulation of inflammation as an anti‐aging intervention
Aging is accompanied by a decline in physiological integrity and a loss of regenerative
capacity in many tissues. The development of interventions that prevent or reverse age …
capacity in many tissues. The development of interventions that prevent or reverse age …
[HTML][HTML] Frailty and cytokines in preclinical models: Comparisons with humans
Chronic low-grade elevations of blood-borne cytokines/chemokines in older age tend to
associate with frailty in humans. This persistent inflammation is often called “inflammageing” …
associate with frailty in humans. This persistent inflammation is often called “inflammageing” …
[HTML][HTML] Kynurenines link chronic inflammation to functional decline and physical frailty
Chronic inflammation is associated with physical frailty and functional decline in older
adults; however, the molecular mechanisms of this linkage are not understood. A mouse …
adults; however, the molecular mechanisms of this linkage are not understood. A mouse …
Elevated serum IL-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
L Ma, G Sha, Y Zhang, Y Li - Clinical interventions in aging, 2018 - Taylor & Francis
Purpose Frailty is associated with adverse health outcomes. Its biological markers are
essential to enhance diagnostic ease and would contribute to surveillance of the condition …
essential to enhance diagnostic ease and would contribute to surveillance of the condition …
[HTML][HTML] Physiological systems in promoting frailty
LR Perazza, HM Brown-Borg… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …
developments have advanced human mortality rates across the world. Our current …
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice
A Kasai, E Jee, Y Tamura, K Kouzaki… - American Journal …, 2022 - journals.physiology.org
Aldehyde dehydrogenase 2 (ALDH2) detoxifies acetaldehyde produced from ethanol. A
missense single nucleotide polymorphism (SNP) rs671 in ALDH2 exhibits a dominant …
missense single nucleotide polymorphism (SNP) rs671 in ALDH2 exhibits a dominant …
Targeted deletion of interleukin-6 in a mouse model of chronic inflammation demonstrates opposing roles in aging: benefit and harm
L Ma, LS Nidadavolu, H Yang… - The Journals of …, 2021 - academic.oup.com
Chronic inflammation (CI) in older adults is associated with reduced health span and life
span. Interleukin-6 (IL-6) is one CI marker that is strongly associated with adverse health …
span. Interleukin-6 (IL-6) is one CI marker that is strongly associated with adverse health …
Rodent models of frailty and their application in preclinical research
In clinical medicine, the concept of frailty is viewed as a state of high vulnerability to adverse
health outcomes in people of the same age. Frailty is an important challenge because the …
health outcomes in people of the same age. Frailty is an important challenge because the …
Effects of eggshell membrane on keratinocyte differentiation and skin aging in vitro and in vivo
K Furukawa, M Kono, T Kataoka, Y Hasebe, H Jia… - Nutrients, 2021 - mdpi.com
Skin aging is one of the hallmarks of the aging process that causes physiological and
morphological changes. Recently, several nutritional studies were conducted to delay or …
morphological changes. Recently, several nutritional studies were conducted to delay or …
Frailty and Caenorhabditis elegans as a Benchtop Animal Model for Screening Drugs Including Natural Herbs
K Matsunami - Frontiers in nutrition, 2018 - frontiersin.org
Caenorhabditis elegans has been used in research for years to clarify the genetic cascades
and molecular mechanisms of aging, longevity, and health span. Health span is closely …
and molecular mechanisms of aging, longevity, and health span. Health span is closely …