Phage therapy for antibiotic-resistant bacterial infections
GF Hatfull, RM Dedrick… - Annual Review of …, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …
infectious diseases. Development of new classes of antibiotics has slowed in recent years …
Genetically engineered phages: a review of advances over the last decade
Soon after their discovery in the early 20th century, bacteriophages were recognized to have
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …
Engineered bacteriophage therapeutics: rationale, challenges and future
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …
Revisiting phage therapy: new applications for old resources
The success of phage therapy is dependent on the development of strategies able to
overcome the limitations of bacteriophages as therapeutic agents, the creation of an …
overcome the limitations of bacteriophages as therapeutic agents, the creation of an …
Genetic engineering of bacteriophages: Key concepts, strategies, and applications
Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …
amount of unexplored genetic information. Since their discovery, phages have drawn a great …
The many applications of engineered bacteriophages—An overview
Since their independent discovery by Frederick Twort in 1915 and Felix d'Herelle in 1917,
bacteriophages have captured the attention of scientists for more than a century. They are …
bacteriophages have captured the attention of scientists for more than a century. They are …
Engineering bacteriophages as versatile biologics
Viruses of bacteria (bacteriophages or phages) are highly evolved nanomachines that
recognize bacterial cell walls, deliver genetic information, and kill or transform their targets …
recognize bacterial cell walls, deliver genetic information, and kill or transform their targets …
Phage-based applications in synthetic biology
Bacteriophage research has been instrumental to advancing many fields of biology, such as
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …
Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting
The rapid rise of antibiotic resistance, combined with the increasing cost and difficulties to
develop new antibiotics, calls for treatment strategies that enable more sustainable antibiotic …
develop new antibiotics, calls for treatment strategies that enable more sustainable antibiotic …
CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages
B Martel, S Moineau - Nucleic acids research, 2014 - academic.oup.com
Bacteriophages are now widely recognized as major players in a wide variety of
ecosystems. Novel genes are often identified in newly isolated phages as well as in …
ecosystems. Novel genes are often identified in newly isolated phages as well as in …