Phage therapy for antibiotic-resistant bacterial infections

GF Hatfull, RM Dedrick… - Annual Review of …, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …

Genetically engineered phages: a review of advances over the last decade

DP Pires, S Cleto, S Sillankorva… - … and Molecular Biology …, 2016 - Am Soc Microbiol
Soon after their discovery in the early 20th century, bacteriophages were recognized to have
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …

Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Revisiting phage therapy: new applications for old resources

FL Nobrega, AR Costa, LD Kluskens, J Azeredo - Trends in microbiology, 2015 - cell.com
The success of phage therapy is dependent on the development of strategies able to
overcome the limitations of bacteriophages as therapeutic agents, the creation of an …

Genetic engineering of bacteriophages: Key concepts, strategies, and applications

W Hussain, X Yang, M Ullah, H Wang, A Aziz… - Biotechnology …, 2023 - Elsevier
Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …

The many applications of engineered bacteriophages—An overview

B Gibb, P Hyman, CL Schneider - Pharmaceuticals, 2021 - mdpi.com
Since their independent discovery by Frederick Twort in 1915 and Felix d'Herelle in 1917,
bacteriophages have captured the attention of scientists for more than a century. They are …

Engineering bacteriophages as versatile biologics

S Kilcher, MJ Loessner - Trends in microbiology, 2019 - cell.com
Viruses of bacteria (bacteriophages or phages) are highly evolved nanomachines that
recognize bacterial cell walls, deliver genetic information, and kill or transform their targets …

Phage-based applications in synthetic biology

S Lemire, KM Yehl, TK Lu - Annual review of virology, 2018 - annualreviews.org
Bacteriophage research has been instrumental to advancing many fields of biology, such as
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …

Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting

DC Angst, B Tepekule, L Sun… - Proceedings of the …, 2021 - National Acad Sciences
The rapid rise of antibiotic resistance, combined with the increasing cost and difficulties to
develop new antibiotics, calls for treatment strategies that enable more sustainable antibiotic …

CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages

B Martel, S Moineau - Nucleic acids research, 2014 - academic.oup.com
Bacteriophages are now widely recognized as major players in a wide variety of
ecosystems. Novel genes are often identified in newly isolated phages as well as in …