An outlook on microfluidics: the promise and the challenge

S Battat, DA Weitz, GM Whitesides - Lab on a Chip, 2022‏ - pubs.rsc.org
This perspective considers ways in which the field of microfluidics can increase its impact by
improving existing technologies and enabling new functionalities. We highlight applications …

Ultrahigh-Throughput Enzyme Engineering and Discovery in In Vitro Compartments

M Gantz, S Neun, EJ Medcalf, LD van Vliet… - Chemical …, 2023‏ - ACS Publications
Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …

Acoustofluidic separation of cells and particles

M Wu, A Ozcelik, J Rufo, Z Wang, R Fang… - Microsystems & …, 2019‏ - nature.com
Acoustofluidics, the integration of acoustics and microfluidics, is a rapidly growing research
field that is addressing challenges in biology, medicine, chemistry, engineering, and …

Single-cell technologies: From research to application

L Wen, G Li, T Huang, W Geng, H Pei, J Yang, M Zhu… - The Innovation, 2022‏ - cell.com
In recent years, more and more single-cell technologies have been developed. A vast
amount of single-cell omics data has been generated by large projects, such as the Human …

Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021‏ - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

A review of current methods in microfluidic device fabrication and future commercialization prospects

BK Gale, AR Jafek, CJ Lambert, BL Goenner… - Inventions, 2018‏ - mdpi.com
Microfluidic devices currently play an important role in many biological, chemical, and
engineering applications, and there are many ways to fabricate the necessary channel and …

Autonomous discovery in the chemical sciences part I: Progress

CW Coley, NS Eyke, KF Jensen - … Chemie International Edition, 2020‏ - Wiley Online Library
This two‐part Review examines how automation has contributed to different aspects of
discovery in the chemical sciences. In this first part, we describe a classification for …

Droplet-based high-throughput single microbe RNA sequencing by smRandom-seq

Z Xu, Y Wang, K Sheng, R Rosenthal, N Liu… - Nature …, 2023‏ - nature.com
Bacteria colonize almost all parts of the human body and can differ significantly. However,
the population level transcriptomics measurements can only describe the average bacteria …

Single-cell barcoding and sequencing using droplet microfluidics

R Zilionis, J Nainys, A Veres, V Savova, D Zemmour… - Nature protocols, 2017‏ - nature.com
Single-cell RNA sequencing has recently emerged as a powerful tool for map** cellular
heterogeneity in diseased and healthy tissues, yet high-throughput methods are needed for …

[HTML][HTML] Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells

AM Klein, L Mazutis, I Akartuna, N Tallapragada… - Cell, 2015‏ - cell.com
It has long been the dream of biologists to map gene expression at the single-cell level. With
such data one might track heterogeneous cell sub-populations, and infer regulatory …