[HTML][HTML] Brain mechanisms of insomnia: new perspectives on causes and consequences

EJW Van Someren - Physiological reviews, 2021‏ - journals.physiology.org
While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Affect and arousal in insomnia: through a lens of neuroimaging studies

JE Schiel, F Holub, R Petri, J Leerssen, S Tamm… - Current Psychiatry …, 2020‏ - Springer
Abstract Purpose of Review Previous research has struggled with identifying clear-cut,
objective counterparts to subjective distress in insomnia. Approaching this discrepancy with …

Towards the neurobiology of insomnia: a systematic review of neuroimaging studies

G Aquino, F Benz, RJ Dressle, A Gemignani, G Alfi… - Sleep Medicine …, 2024‏ - Elsevier
Insomnia disorder signifies a major public health concern. The development of
neuroimaging techniques has permitted to investigate brain mechanisms at a structural and …

Efficacy of transcranial alternating current stimulation in treating chronic insomnia and the impact of age on its effectiveness: a multisite randomized, double-blind …

X Zhu, Y Ren, S Tan, X Ma - Journal of Psychiatric Research, 2024‏ - Elsevier
Objective Insomnia is a significant health issue associated with various systemic diseases.
Transcranial alternating current stimulation (tACS) has been proposed as a potential …

White matter microstructural abnormalities in primary insomnia: a systematic review of diffusion tensor imaging studies

HS Moghaddam, E Mohammadi, M Dolatshahi… - Progress in Neuro …, 2021‏ - Elsevier
Primary insomnia (PI), the most common sleep disorder, is primarily characterized by
difficulties in initiating and maintaining sleep and deficits in daytime functioning. Study of …

The role of brain white matter in depression resilience and response to sleep interventions

T Bresser, J Leerssen, S Hölsken, I Groote… - Brain …, 2023‏ - academic.oup.com
Insomnia poses a high risk for depression. Brain mechanisms of sleep and mood
improvement following cognitive behavioural therapy for insomnia remain elusive. This …

Sleep alterations in major depressive disorder and insomnia disorder: a network meta-analysis of polysomnographic studies

C Leitner, F Dalle Piagge, T Tomic, F Nozza… - Sleep Medicine …, 2025‏ - Elsevier
Major depressive disorder (MDD) and Insomnia disorder (ID) are characterized by sleep
alterations. To define their polysomnographic profiles, we conducted a Network Meta …

Frontal white matter association with sleep quality and the role of stress

HA Bruce, P Kochunov, MD Kvarta… - Journal of sleep …, 2023‏ - Wiley Online Library
An important measure of brain health is the integrity of white matter connectivity structures
that link brain regions. Studies have found an association between poorer sleep quality and …

Lifetime depression, sleep disruption and brain structure in the UK Biobank cohort

LM Lyall, A Stolicyn, DM Lyall, X Zhu, N Sangha… - Journal of Affective …, 2025‏ - Elsevier
Whether depression and poor sleep interact or have statistically independent associations
with brain structure and its change over time is not known. Within a subset of UK Biobank …

Sleep quality disturbances are associated with white matter alterations in veterans with post-traumatic stress disorder and mild traumatic brain injury

P Rojczyk, J Seitz-Holland, E Kaufmann… - Journal of clinical …, 2023‏ - mdpi.com
Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-
traumatic stress disorder (PTSD). PTSD and mTBI have been linked to alterations in white …