Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a
range of neurodegenerative diseases. Tau filaments adopt different conformations in …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …

Oligomerization of tau is a key process contributing to the progressive death of neurons in
Alzheimer's disease. Tau is modified by O-linked N-acetylglucosamine (O-GlcNAc), and O …

Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in
Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent …

Alzheimer's disease (AD) remains an incurable disease and lacks efficient diagnostic
methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it …

Emodin (6-methyl-1, 3, 8-trihydroxyanthraquinone) is a naturally occurring anthraquinone
derivative found in roots and leaves of various plants, fungi and lichens. For a long time it …

Neuronal inclusions comprised of the microtubule-associated protein tau are found in
numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's …