Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Ancient pathogen genomics as an emerging tool for infectious disease research

MA Spyrou, KI Bos, A Herbig, J Krause - Nature Reviews Genetics, 2019 - nature.com
Over the past decade, a genomics revolution, made possible through the development of
high-throughput sequencing, has triggered considerable progress in the study of ancient …

A draft sequence of the Neandertal genome

RE Green, J Krause, AW Briggs, T Maricic, U Stenzel… - science, 2010 - science.org
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of
Europe and western Asia before disappearing 30,000 years ago. We present a draft …

Genetic history of an archaic hominin group from Denisova Cave in Siberia

D Reich, RE Green, M Kircher, J Krause, N Patterson… - Nature, 2010 - nature.com
Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we
have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This …

Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform

M Kircher, S Sawyer, M Meyer - Nucleic acids research, 2012 - academic.oup.com
Due to the increasing throughput of current DNA sequencing instruments, sample
multiplexing is necessary for making economical use of available sequencing capacities. A …

A revised timescale for human evolution based on ancient mitochondrial genomes

Q Fu, A Mittnik, PLF Johnson, K Bos, M Lari… - Current biology, 2013 - cell.com
Background Recent analyses of de novo DNA mutations in modern humans have suggested
a nuclear substitution rate that is approximately half that of previous estimates based on …

Neandertal and Denisovan DNA from Pleistocene sediments

V Slon, C Hopfe, CL Weiß, F Mafessoni… - Science, 2017 - science.org
Although a rich record of Pleistocene human-associated archaeological assemblages
exists, the scarcity of hominin fossils often impedes the understanding of which hominins …

Ancient human genome sequence of an extinct Palaeo-Eskimo

M Rasmussen, Y Li, S Lindgreen, JS Pedersen… - Nature, 2010 - nature.com
We report here the genome sequence of an ancient human. Obtained from∼ 4,000-year-old
permafrost-preserved hair, the genome represents a male individual from the first known …

Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs

O Thalmann, B Shapiro, P Cui, VJ Schuenemann… - Science, 2013 - science.org
The geographic and temporal origins of the domestic dog remain controversial, as genetic
data suggest a domestication process in East Asia beginning 15,000 years ago, whereas …

[BOOK][B] Human evolutionary genetics: origins, peoples and disease

M Jobling, C Tyler-Smith - 2019 - taylorfrancis.com
Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …