Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …

Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of
Alzheimer's disease (AD). Loss of synapses between basal forebrain and hippocampal and …

During neuronal development, neurotrophins are essential factors that promote survival,
differentiation and myelination of neurons. The trophic signals are relayed to the cells via …

Although identified almost 20 years ago, the precise physiological role of the p75
neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that …

Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the
capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via …

Background Exposure to anesthetics during synaptogenesis results in apoptosis and
subsequent cognitive dysfunction in adulthood. Probrain derived neurotrophic factor …

Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …

The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated
protein (MAP) kinase (p38) regulate apoptosis induced by several forms of cellular insults …

The innate immune system relies on evolutionally conserved Toll-like receptors (TLRs) to
recognize diverse microbial molecular structures. Most TLRs depend on a family of adaptor …

Neurotrophins were christened in consideration of their actions on the nervous system and,
for a long time, they were the exclusive interest of neuroscientists. However, more recently …