SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

The emergence of SARS-CoV-2 Omicron subvariants: current situation and future trends

RA Farahat, A Abdelaal, TP Umar… - Le infezioni in …, 2022 - pmc.ncbi.nlm.nih.gov
SUMMARY The SARS-CoV-2 Omicron variant (B. 1.1. 529) has been the most recent variant
of concern (VOC) established by the World Health Organization (WHO). Because of its …

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

TP Peacock, JC Brown, J Zhou, N Thakur, K Sukhova… - biorxiv, 2022 - biorxiv.org
At the end of 2021 a new SARS-CoV-2 variant, Omicron, emerged and quickly spread
across the world. It has been demonstrated that Omicron's high number of Spike mutations …

Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice

F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …

[HTML][HTML] Rapid escape of new SARS-CoV-2 Omicron variants from BA. 2-directed antibody responses

A Dijokaite-Guraliuc, R Das, D Zhou, HM Ginn, C Liu… - Cell Reports, 2023 - cell.com
Summary In November 2021, Omicron BA. 1, containing a raft of new spike mutations,
emerged and quickly spread globally. Intense selection pressure to escape the antibody …

Double-antibody-based nano-biosensing system for the onsite monitoring of SARS-CoV-2 variants

HA Hussein, A Kandeil, M Gomaa… - Microsystems & …, 2023 - nature.com
The fast and reliable diagnosis of COVID-19 is the foremost priority for promoting public
health interventions. Therefore, double-antibody-based immunobiosensor chips were …

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

KS Lee, TY Wong, BP Russ, AM Horspool, OA Miller… - Plos one, 2022 - journals.plos.org
The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC)
that have increased transmissibility, receptor binding affinity, and other properties that …

Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both

S Beitari, G Agbayani, M Hewitt, D Duque… - Scientific Reports, 2023 - nature.com
A critical feature of the VSV vector platform is the ability to pseudotype the virus with different
glycoproteins from other viruses, thus altering cellular tropism of the recombinant virus. The …

Experimental co-infection of calves with SARS-CoV-2 Delta and Omicron variants of concern

K Cool, NN Gaudreault, JD Trujillo… - Emerging Microbes & …, 2024 - Taylor & Francis
Since emerging in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has repeatedly crossed the species barrier with natural infections reported in various …

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model

M Cochin, L Luciani, F Touret, JS Driouich… - Communications …, 2022 - nature.com
Abstract Late 2020, SARS-CoV-2 Alpha variant emerged in United Kingdom and gradually
replaced G614 strains initially involved in the global spread of the pandemic. In this study …