Regulatory network and targeted interventions for CCDC family in tumor pathogenesis

Z Liu, W Yan, S Liu, Z Liu, P Xu, W Fang - Cancer letters, 2023 - Elsevier
CCDC (coiled-coil domain-containing) is a coiled helix domain that exists in natural proteins.
There are about 180 CCDC family genes, encoding proteins that are involved in intercellular …

Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis

Z Jia, M Zheng, J Jiang, D Cao, Y Wu, Y Zhang, Y Fu… - BMC cancer, 2022 - Springer
Background Previous researches have associated Helicobacter pylori (H. pylori) with a
prognosis of gastric cancer (GC), however, without a concert conclusion. This study aimed to …

Protective effect of mulberry (Morus atropurpurea) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota

TG Hu, P Wen, HZ Fu, GY Lin, ST Liao, YX Zou - Food & Function, 2019 - pubs.rsc.org
Mulberry (Morus atropurpurea) has long been used to treat gastro-intestinal ailments;
however, the functional basis of its therapeutic effects remains unclear. The aim of this study …

Application of molecular techniques in Helicobacter pylori detection: limitations and improvements.

L Gong, EM El‐Omar - Helicobacter, 2021 - search.ebscohost.com
I pylori i strains with certain I vacA iI cagA i genotypes in gastric biopsies. 28 Hence, it would
be important to detect and treat this undetected infection to prevent further transmission …

Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin β-1/NF-κB signaling pathway

Y Hu, JP Liu, XY Li, Y Cai, C He, NS Li, C **e, ZJ **ong… - Cancer letters, 2019 - Elsevier
Receptor of activated protein kinase C 1 (RACK1) is downregulated in gastric cancer and is
involved in modulating NF-κB signaling pathway activity. However, the underlying molecular …

Hippo-YAP signaling in digestive system tumors

F Yin, J Dong, LI Kang, X Liu - American Journal of Cancer …, 2021 - pmc.ncbi.nlm.nih.gov
The Hippo pathway is an evolutionally conserved pathway and plays an important role in
regulating tissue hemostasis and organ size control. Deregulation of the Hippo pathway is …

[HTML][HTML] Identification of CXCL13 as a potential biomarker in clear cell renal cell carcinoma via comprehensive bioinformatics analysis

T Xu, H Ruan, Z Song, Q Cao, K Wang, L Bao… - Biomedicine & …, 2019 - Elsevier
Background Clear cell renal cell carcinoma (ccRCC) is one of the most common
malignancies in urinary system. However, there are still no reliable biomarkers for the …

VSTM2L contributes to anoikis resistance and acts as a novel biomarker for metastasis and clinical outcome in ovarian cancer

Y Li, J Zhang, Y Cai, H Liu, W Yang, Y Xu… - … and biophysical research …, 2023 - Elsevier
The majority of patients are diagnosed when ovarian cancer (OC) has metastasized, making
surgery and chemotherapy less effective. Thus, there is an urgent need to elucidate the …

Helicobacter pylori activates DOPEY1 to promote p53 degradation through the USP7/TRIP12 axis in gastric tumorigenesis

YA Zhou, NS Li, YC Zhu, ZK He, Y Ouyang, LX Ling… - Oncogene, 2025 - nature.com
DOP1 leucine zipper-like protein A (DOPEY1), a member of the DOPEY family, is mainly
localized in the Golgi apparatus, endosomes, and cytoplasmic compartments within cells …

MIF-modulated spinal proteins associated with persistent bladder pain: A proteomics study

S Ye, NM Agalave, F Ma, DFD Mahmood… - International Journal of …, 2024 - mdpi.com
Bladder pain is a prominent symptom in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
We studied spinal mechanisms of bladder pain in mice using a model where repeated …