The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

The human brain is arguably the most complex structure among living organisms. However,
the specific mechanisms leading to this complexity remain incompletely understood …

Neurogenesis processes differ in different areas of the cortex in many species, including
humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and …

During human brain development, multiple signaling pathways generate diverse cell types
with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal …

The relationships between impaired cortical development and consequent malformations in
neurodevelopmental disorders, as well as the genes implicated in these processes, are not …

The development of the cerebral cortex requires the tightly coordinated generation of
dozens of neuronal subtypes that will populate specific layers and areas. Recent studies …

Neurons derived from embryonic stem cells (ESCs) have gained great merit in both basic
research and regenerative medicine. Here we review and summarize the signaling …

Background A widespread modulation of gene expression occurs in the aging brain, but little
is known as to the upstream drivers of these changes. MicroRNAs emerged as fine …

Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for
patterning, development, and function of the central and peripheral nervous system. Their …

Embryonic Stem cells derived from the epiblast tissue of the mammalian blastocyst retain the
capability to differentiate into any adult cell type and are able to self-renew indefinitely under …