To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Microfluidic technologies employ nano and microscale fabrication techniques to develop
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

Coupled systems of in vitro microfabricated organs-on-a-chip containing small populations
of human cells are being developed to address the formidable pharmacological and …

A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside
nanoparticles to prolong blood circulation time and to enhance interactions with targeted …

Tissue engineering and regenerative medicine have made great progress in recent
decades, as the fields of bioengineering, materials science, and stem cell biology have …

The importance of studying angiogenesis, the formation of new blood vessels from pre-
existing vessels, is underscored by its involvement in both normal physiology, such as …

Abstract “Margination” refers to the movement of particles in flow toward the walls of a
channel. The term was first coined in physiology for describing the behavior of white blood …

Protein Kinase C (PKC) is a family composed of phospholipid-dependent serine/threonine
kinases that are master regulators of inflammatory signaling. The activity of different PKCs is …

Cell–fluid and cell–cell interactions are critical components of many physiological and
pathological conditions in the microvasculature. Similarly, particle–cell interactions play an …