Circadian regulation of glucose, lipid, and energy metabolism in humans
The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms
organize metabolism by temporally separating opposing metabolic processes and by …
organize metabolism by temporally separating opposing metabolic processes and by …
Adipose tissue as an endocrine organ
The discovery of leptin in the mid-1990s has focused attention on the role of proteins
secreted by adipose tissue. Leptin has profound effects on appetite and energy balance …
secreted by adipose tissue. Leptin has profound effects on appetite and energy balance …
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
DE Cummings, JQ Purnell, RS Frayo, K Schmidova… - Diabetes, 2001 - Am Diabetes Assoc
The recently discovered orexigenic peptide ghrelin is produced primarily by the stomach
and circulates in blood at levels that increase during prolonged fasting in rats. When …
and circulates in blood at levels that increase during prolonged fasting in rats. When …
Adverse metabolic and cardiovascular consequences of circadian misalignment
FAJL Scheer, MF Hilton… - Proceedings of the …, 2009 - National Acad Sciences
There is considerable epidemiological evidence that shift work is associated with increased
risk for obesity, diabetes, and cardiovascular disease, perhaps the result of physiologic …
risk for obesity, diabetes, and cardiovascular disease, perhaps the result of physiologic …
The metabolic consequences of sleep deprivation
The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the
causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior …
causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior …
[HTML][HTML] Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes
Chronic sleep loss as a consequence of voluntary bedtime restriction is an endemic
condition in modern society. Although sleep exerts marked modulatory effects on glucose …
condition in modern society. Although sleep exerts marked modulatory effects on glucose …
[HTML][HTML] Fructose, weight gain, and the insulin resistance syndrome
This review explores whether fructose consumption might be a contributing factor to the
development of obesity and the accompanying metabolic abnormalities observed in the …
development of obesity and the accompanying metabolic abnormalities observed in the …
Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin
K Spiegel, R Leproult… - The Journal of …, 2004 - academic.oup.com
Sleep plays an important role in energy homeostasis. The present study tests the hypothesis
that circulating levels of leptin, a hormone that signals energy balance to the brain, are …
that circulating levels of leptin, a hormone that signals energy balance to the brain, are …
Shift work: disrupted circadian rhythms and sleep—implications for health and well-being
Abstract Purpose of Review Our 24/7 society is dependent on shift work, despite mounting
evidence for negative health outcomes from sleep displacement due to shift work. This …
evidence for negative health outcomes from sleep displacement due to shift work. This …
Circadian misalignment and health
KG Baron, KJ Reid - International review of psychiatry, 2014 - Taylor & Francis
Circadian rhythms are near 24-h patterns of physiology and behaviour that are present
independent of external cues including hormones, body temperature, mood, and sleep …
independent of external cues including hormones, body temperature, mood, and sleep …