Using clusterProfiler to characterize multiomics data

S Xu, E Hu, Y Cai, Z **e, X Luo, L Zhan, W Tang… - Nature protocols, 2024 - nature.com
With the advent of multiomics, software capable of multidimensional enrichment analysis
has become increasingly crucial for uncovering gene set variations in biological processes …

The evolution of single-cell RNA sequencing technology and application: progress and perspectives

S Wang, ST Sun, XY Zhang, HR Ding, Y Yuan… - International journal of …, 2023 - mdpi.com
As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

[HTML][HTML] Immunostimulatory effects of thermal ablation: Challenges and future prospects

P Liu, Z Wei, X Ye - Journal of Cancer Research and …, 2024 - journals.lww.com
This literature explores the immunostimulatory effects of thermal ablation in the tumor
microenvironment, elucidating the mechanisms such as immunogenic cell death, tumor …

[HTML][HTML] Photothermal therapy improves the efficacy of topical immunotherapy against melanoma

L Shi, F Zhang, J Yan, M Luo, K Liu, P Liu, G Yan… - Photodiagnosis and …, 2024 - Elsevier
Background Melanoma is an aggressive cancer with poor response to traditional therapies.
A combination of photothermal therapy and topical immunotherapy may enhance …

[HTML][HTML] Localized ablative immunotherapy enhances antitumor immunity by modulating the transcriptome of tumor-infiltrating Gamma delta T cells

K Liu, AR Hoover, L Wang, Y Sun, TI Valerio, C Furrer… - Cancer Letters, 2024 - Elsevier
Gamma delta T cells (γδT cells) play crucial roles in the immune response against tumors,
yet their functional dynamics under different cancer therapies remain poorly understood …

[HTML][HTML] N-dihydrogalactochitosan serves as an effective mucosal adjuvant for intranasal vaccine in combination with recombinant viral proteins against respiratory …

AR Hoover, S More, K Liu, CL West, TI Valerio… - Acta Biomaterialia, 2024 - Elsevier
Mucosal vaccinations for respiratory pathogens provide effective protection as they stimulate
localized cellular and humoral immunities at the site of infection. Currently, the major …

Immune modulations of the tumor microenvironment in response to phototherapy

TI Valerio, CL Furrer, N Sadeghipour… - Journal of innovative …, 2023 - World Scientific
The tumor microenvironment (TME) promotes pro-tumor and anti-inflammatory metabolisms
and suppresses the host immune system. It prevents immune cells from fighting against …

N‐Dihydrogalactochitosan Drives Conventional and Alternative Activations of STING to Synergize Type I IFN and IL‐1β Productions for Antitumor Immunity.

AR Hoover, K Liu, C Furrer, SSK Lam… - Advanced Functional …, 2024 - Wiley Online Library
N‐dihydrogalactochitosan (GC) is an immune stimulant/adjuvant. Synthesized from chitosan
and galactose, GC is a new chemical entity that significantly enhances the immune …

Amino acids and their roles in tumor immunotherapy of breast cancer

H **a, J Zhu, Z Zheng, P **ao, X Yu… - The Journal of Gene …, 2024 - Wiley Online Library
Breast cancer is the most commonly diagnosed cancer among women. The primary
treatment options include surgery, radiotherapy, chemotherapy, targeted therapy and …

Localized ablative immunotherapy drives de novo CD8+ T-cell responses to poorly immunogenic tumors

AR Hoover, S Kaabinejadian, JR Krawic… - Journal for …, 2022 - pmc.ncbi.nlm.nih.gov
Background Localized ablative immunotherapies hold great promise in stimulating antitumor
immunity to treat metastatic and poorly immunogenic tumors. Tumor ablation is well known …