Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular
signaling. However, ROS level is dramatically elevated due to abnormal metabolism during …

Boronic acid (and ester) prodrugs targeting the overexpressed level of reactive oxygen
species within tumor microenvironment represent a promising area for the discovery of new …

Smart drugs, such as antibody‐drug conjugates, for targeted therapy rely on the ability to
deliver a warhead to the desired location and to achieve activation at the same site. Thus …

Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical
research due to their exceptional oxophilicity, low toxicity, and unique structure. They are …

Prodrugs are pharmacologically inactive, chemically modified derivatives of active drugs,
which, following in vivo administration, are converted to the parent drugs through chemical …

Approved anticancer drugs typically face challenges due to their narrow therapeutic window,
primarily because of high systemic toxicity and limited selectivity for tumors. Prodrugs are …

Hydrogen peroxide is the most stable reactive oxygen species generated endogenously,
participating in numerous physiological processes and abnormal pathological conditions …

Hydrogen sulfide (H2S) is an endogenous signaling molecule that greatly influences several
important (patho) physiological processes related to cardiovascular health and disease …