Recent studies are reviewed indicating that the transcription factor early growth response-1
(Egr1) is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and …

Resveratrol (3, 4′, 5-trihydroxystilbene), a naturally occurring phytoalexin readily available
in the diet, is reported to possess both chemopreventive and chemotherapeutic activities in …

Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …

Activation in transformed cells of normal stem cells' self-renewal pathways might contribute
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …

The transcription factor EGR1 is a tumor suppressor gene that is downregulated in many
cancer types. Clinically, loss of EGR1 translates to increased tumor transformation and …

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological
processes that can contribute to cancer. Although tumor-suppressive and oncogenic …

The presence of atypical cytoskeletal dynamics, structures, and associated morphologies is
a common theme uniting numerous diseases and developmental disorders. In particular …

Bone is the most frequent site of prostate cancer (PCa) metastasis; however, little is known
about the role of the most common cell in bone, the osteocyte (OCy), in cancer biology. In …

IL-15 has potential as an immunotherapeutic agent for cancer treatment because of its ability
to effectively stimulate CD8 T cell, natural killer T cell, and natural killer cell immunity …

The early growth response 1 (Egr1) gene is a transcription factor that acts as both a tumor
suppressor and a tumor promoter. Egr1-null mouse embryo fibroblasts bypass replicative …