MiRNA-based therapies for lung cancer: opportunities and challenges?

H Yang, Y Liu, L Chen, J Zhao, M Guo, X Zhao, Z Wen… - Biomolecules, 2023 - mdpi.com
Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related
deaths, posing a serious health risk. Despite new advances in immune checkpoint and …

Cell death pathways of particulate matter toxicity

MS Peixoto, MF de Oliveira Galvão, SRB de Medeiros - Chemosphere, 2017 - Elsevier
Humans are exposed to various complex mixtures of particulate matter (PM) from different
sources. Long-term exposure to high levels of these particulates has been linked to a …

Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice

Y Liu, R Palanivel, E Rai, M Park, TV Gabor… - Diabetes, 2015 - diabetesjournals.org
Numerous studies have characterized the antidiabetic effects of adiponectin, yet the precise
cellular mechanisms in skeletal muscle, in particular, changes in autophagy, require further …

Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium

T Nunes, C Bernardazzi… - BioMed research …, 2014 - Wiley Online Library
Cell death mechanisms have been associated with the development of inflammatory bowel
diseases in humans and mice. Recent studies suggested that a complex crosstalk between …

Sodium butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis in …

F Wang, H Wu, M Fan, R Yu, Y Zhang, J Liu… - The FASEB …, 2020 - Wiley Online Library
Bladder cancer is one of the most frequently occurring malignant tumors in the urinary
system. Sodium butyrate (NaB) is a histone deacetylase inhibitor and exerts remarkable …

Hydrogen sulfide and autophagy: a double edged sword

D Wu, H Wang, T Teng, S Duan, A Ji, Y Li - Pharmacological research, 2018 - Elsevier
Hydrogen sulfide (H 2 S) has been considered the third gaseous signaling molecule that
plays important roles in a wide range of physiological and pathological conditions. However …

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

T Khan, N Relitti, M Brindisi, S Magnano… - Medicinal Research …, 2020 - Wiley Online Library
Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas
(ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis …

Mechanisms underlying curcumin-induced neuroprotection in cerebral ischemia

F Fan, M Lei - Frontiers in Pharmacology, 2022 - frontiersin.org
Ischemic stroke is the leading cause of death and disability worldwide, and restoring the
blood flow to ischemic brain tissues is currently the main therapeutic strategy. However …

A double negative feedback loop between mTORC1 and AMPK kinases guarantees precise autophagy induction upon cellular stress

M Holczer, B Hajdú, T Lőrincz, A Szarka… - International journal of …, 2019 - mdpi.com
Cellular homeostasis is controlled by an evolutionary conserved cellular digestive process
called autophagy. This mechanism is tightly regulated by the two sensor elements called …

Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells

F Lang, Z Qin, F Li, H Zhang, Z Fang, E Hao - PloS one, 2015 - journals.plos.org
Resveratrol (trans-3, 4, 5'–trihydroxystilbene) is an active compound in food, such as red
grapes, peanuts, and berries. Resveratrol exhibits an anticancer effect on various human …