The vertebrate control of locomotion involves all levels of the nervous system from cortex to
the spinal cord. Here, we aim to cover all main aspects of this complex behavior, from the …

Unravelling the functional operation of neuronal networks and linking cellular activity to
specific behavioural outcomes are among the biggest challenges in neuroscience. In this …

A spinal cord injury interrupts pathways from the brain and brainstem that project to the
lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural …

To understand the cellular basis of behavior, it is necessary to know the cell types that exist
in the nervous system and their contributions to function. Spinal networks are essential for …

Spinal cord injuries alter motor function by disconnecting neural circuits above and below
the lesion, rendering sensory inputs a primary source of direct external drive to neuronal …

We present Augur, a method to prioritize the cell types most responsive to biological
perturbations in single-cell data. Augur employs a machine-learning framework to quantify …

The episodic nature of locomotion is thought to be controlled by descending inputs from the
brainstem. Most studies have largely attributed this control to initiating excitatory signals, but …

Animals generate movement by engaging spinal circuits that direct precise sequences of
muscle contraction, but the identity and organizational logic of local interneurons that lie at …

Walking is a complex motor programme involving coordinated and distributed activity across
the brain and the spinal cord. Halting appropriately at the correct time is a critical component …

The spinal cord integrates and relays somatosensory input, leading to complex motor
responses. Research over the past couple of decades has identified transcription factor …