[HTML][HTML] Biomolecular feedback controllers: from theory to applications
Highlights•Synthetic biomolecular feedback controllers have promising applications in
various fields.•Negative-feedback controllers enhance dynamic performance and reduce …
various fields.•Negative-feedback controllers enhance dynamic performance and reduce …
A cybergenetic framework for engineering intein-mediated integral feedback control systems
The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …
A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
Abstract Proportional-Integral-Derivative (PID) feedback controllers are the most widely used
controllers in industry. Recently, the design of molecular PID-controllers has been identified …
controllers in industry. Recently, the design of molecular PID-controllers has been identified …
Cybergenetics: Theory and applications of genetic control systems
MH Khammash - Proceedings of the IEEE, 2022 - ieeexplore.ieee.org
There is no design template more important than DNA. Within the sequences of this
exquisite substance lie the design plans for each of us and for every living organism …
exquisite substance lie the design plans for each of us and for every living organism …
Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles
Engineered signaling networks can impart cells with new functionalities useful for directing
differentiation and actuating cellular therapies. For such applications, the engineered …
differentiation and actuating cellular therapies. For such applications, the engineered …
Control of mammalian cell-based devices with genetic programming
Synthetic biology increasingly enables the construction of sophisticated functions in
mammalian cells. A particularly promising frontier combines concepts drawn from industrial …
mammalian cells. A particularly promising frontier combines concepts drawn from industrial …
Anti-windup strategies for biomolecular control systems facilitated by model reduction theory for sequestration networks
Robust perfect adaptation, a system property whereby a variable adapts to persistent
perturbations at steady state, has been recently realized in living cells using genetic integral …
perturbations at steady state, has been recently realized in living cells using genetic integral …
Exploiting the nonlinear structure of the antithetic integral controller to enhance dynamic performance
The design of biomolecular feedback controllers has been identified as an important goal
across a broad range of biological applications spanning synthetic biology, cell therapy …
across a broad range of biological applications spanning synthetic biology, cell therapy …
Dichotomous feedback: a signal sequestration-based feedback mechanism for biocontroller design
We introduce a new design framework for implementing negative feedback regulation in
synthetic biology, which we term 'dichotomous feedback'. Our approach is different from …
synthetic biology, which we term 'dichotomous feedback'. Our approach is different from …
Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model
N Liu, H Yang, L Yang - Physica D: Nonlinear Phenomena, 2024 - Elsevier
The p53 protein is essential for cancer prevention. Research on p53 mathematical models is
popular since its oscillatory dynamics were observed. However, there is little research on …
popular since its oscillatory dynamics were observed. However, there is little research on …