Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
Erythropoietin‐mediated tissue protection: reducing collateral damage from the primary injury response
M Brines, A Cerami - Journal of internal medicine, 2008 - Wiley Online Library
In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates
the number of erythrocytes within the circulation to provide adequate tissue oxygenation …
the number of erythrocytes within the circulation to provide adequate tissue oxygenation …
Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy
Ocular neovascularization (NV) is the primary cause of blindness in a wide range of ocular
diseases, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) …
diseases, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) …
Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head …
I Yatsiv, N Grigoriadis, C Simeonidou… - The FASEB …, 2005 - Wiley Online Library
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young people in
industrialized countries. Although various anti‐inflammatory and antiapoptotic modalities …
industrialized countries. Although various anti‐inflammatory and antiapoptotic modalities …
Regulation of erythropoietin production
KU Eckardt, A Kurtz - European journal of clinical investigation, 2005 - Wiley Online Library
The glycoprotein hormone erythropoietin (EPO) is an essential growth and survival factor for
erythroid progenitor cells, and the rate of red blood cell production is normally determined by …
erythroid progenitor cells, and the rate of red blood cell production is normally determined by …
Hypoxia-inducible factor-1α target genes contribute to retinal neuroprotection
L Cheng, H Yu, N Yan, K Lai, M ** in cycling: lack of evidence for efficacy and a negative risk–benefit
JAAC Heuberger, JM Cohen Tervaert… - British journal of …, 2013 - Wiley Online Library
Imagine a medicine that is expected to have very limited effects based upon knowledge of its
pharmacology and (patho) physiology and that is studied in the wrong population, with low …
pharmacology and (patho) physiology and that is studied in the wrong population, with low …
Erythropoietin protects the intestine against ischemia/reperfusion injury in rats
Previous studies have shown that erythropoietin (EPO) has protective effects against
ischemia/reperfusion (I/R) injury in several tissues. The aim of this study was to determine …
ischemia/reperfusion (I/R) injury in several tissues. The aim of this study was to determine …
Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing: the “normobaric oxygen paradox”
C Balestra, P Germonpré… - Journal of Applied …, 2006 - journals.physiology.org
Renal (peritubular) tissue hypoxia is a well-known physiological trigger for erythropoietin
(EPO) production. We investigated the effect of rebound relative hypoxia after hyperoxia …
(EPO) production. We investigated the effect of rebound relative hypoxia after hyperoxia …