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Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …
safe and effective treatments are available. However, new approaches to symptom …
Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?
KA Jellinger, AD Korczyn - Advances in Surgical and Medical …, 2023 - taylorfrancis.com
The clinical features of dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD) are similar and include dementia, cognitive fluctuations, and (visual) hallucinations in …
(PDD) are similar and include dementia, cognitive fluctuations, and (visual) hallucinations in …
Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies
KA Jellinger - Journal of neural transmission, 2018 - Springer
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …
Towards a global view of Parkinson's disease genetics
Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have
taken place predominantly in European populations. Recent genetics research conducted in …
taken place predominantly in European populations. Recent genetics research conducted in …
[HTML][HTML] Cognitive impairment in Parkinson's disease: epidemiology, clinical profile, protective and risk factors
Cognitive impairment is a common non-motor symptom in Parkinson's Disease (PD) and an
important source of patient disability and caregiver burden. The timing, profile and rate of …
important source of patient disability and caregiver burden. The timing, profile and rate of …
New therapeutic approaches to Parkinson's disease targeting GBA, LRRK2 and Parkin
Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …
The genetics of dementia with Lewy bodies: current understanding and future directions
Abstract Purpose of Review Dementia with Lewy bodies (DLB) is a neurodegenerative
disease that can be clinically and pathologically similar to Parkinson's disease (PD) and …
disease that can be clinically and pathologically similar to Parkinson's disease (PD) and …
Glucocerebrosidase mutations and synucleinopathies: toward a model of precision medicine
Glucocerebrosidase is a lysosomal enzyme. The characterization of a direct link between
mutations in the gene coding for glucocerebrosidase (GBA1) with the development of …
mutations in the gene coding for glucocerebrosidase (GBA1) with the development of …
GBA Variants in Parkinson's Disease: Clinical, Metabolomic, and Multimodal Neuroimaging Phenotypes
Background Alterations in the GBA gene (NM_000157. 3) are the most important genetic risk
factor for Parkinson's disease (PD). Biallelic GBA mutations cause the lysosomal storage …
factor for Parkinson's disease (PD). Biallelic GBA mutations cause the lysosomal storage …
Mutational spectrum and clinical features of GBA1 variants in a Chinese cohort with Parkinson's disease
Y Zhou, Y Wang, J Wan, Y Zhao, H Pan, Q Zeng… - npj Parkinson's …, 2023 - nature.com
GBA1 variants are important risk factors for Parkinson's disease (PD). Most studies
assessing GBA1-related PD risk have been performed in European-derived populations …
assessing GBA1-related PD risk have been performed in European-derived populations …