The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

DNA sensing is a pivotal component of the innate immune system that is responsible for
detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Degeneration of photoreceptors in age-related macular degeneration (AMD) is associated
with oxidative stress due to the intense aerobic metabolism of rods and cones that if not …

Chemokines and their corresponding receptors play crucial roles in orchestrating
inflammatory and immune responses, particularly in the context of pathological conditions …

Autophagy is a conserved mechanism that degrades damaged or superfluous cellular
contents and enables nutrient recycling under starvation conditions. Many …

Defective DNA damage signalling and repair is a hallmark of age-related and genetic
neurodegenerative disease. One mechanism implicated in disease progression is DNA …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by
progressive cognitive decline and the accumulation of amyloid-beta plaques, tau tangles …