The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease
Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …
A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …
considerable part from synaptic dysfunction caused by the accumulation of a range of …
Deciphering cell–cell communication at single-cell resolution for spatial transcriptomics with subgraph-based graph attention network
The inference of cell–cell communication (CCC) is crucial for a better understanding of
complex cellular dynamics and regulatory mechanisms in biological systems. However …
complex cellular dynamics and regulatory mechanisms in biological systems. However …
Synaptic impairment in Alzheimer's disease: a dysregulated symphony
Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …
[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease
Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …
The toxicity and polymorphism of β-amyloid oligomers
Y Huang, R Liu - International journal of molecular sciences, 2020 - mdpi.com
It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …
Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease
Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …
responsible for memory and learning. It plays a key role in modulating rapid changes in …
Amyloid β oligomers (AβOs) in Alzheimer's disease
B Mroczko, M Groblewska, A Litman-Zawadzka… - Journal of Neural …, 2018 - Springer
The causative role of amyloid β 1–42 (Aβ42) aggregation in the pathogenesis of Alzheimer's
disease (AD) has been under debate for over 25 years. Primarily, scientific efforts have …
disease (AD) has been under debate for over 25 years. Primarily, scientific efforts have …
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner
KS Abd-Elrahman, A Albaker, JM de Souza… - Science …, 2020 - science.org
The prevalence, presentation, and progression of Alzheimer's disease (AD) differ between
men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in …
men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in …