Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic
feature is persistent itching of the skin. The chronic, relapsing course of the disease …

Functioning as the exterior interface of the human body with the environment, skin acts as a
physical barrier to prevent the invasion of foreign pathogens while providing a home to the …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …

The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

Atopic dermatitis (AD) is a common disease that is associated with atopic and nonatopic
comorbidities. There has been a growing interest in this area of AD, because presence or …

Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …

Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …

Genome-wide association studies have identified many loci associated with hair and skin
disease, but identification of causal variants requires deciphering of gene-regulatory …