Quantitative systems pharmacology: an exemplar model‐building workflow with applications in cardiovascular, metabolic, and oncology drug development
Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and
disease modeling, seeks to address a diverse set of problems in the discovery and …
disease modeling, seeks to address a diverse set of problems in the discovery and …
In silico models in drug development: where we are
Highlights•A variety of computational methods and tools are used in QSP and QST. They
show different degrees of maturity.•PBPK models are well established and applied in a wide …
show different degrees of maturity.•PBPK models are well established and applied in a wide …
Applications of quantitative systems pharmacology in model‐informed drug discovery: perspective on impact and opportunities
EL Bradshaw, ME Spilker, R Zang… - CPT …, 2019 - Wiley Online Library
Quantitative systems pharmacology (QSP) approaches have been increasingly applied in
the pharmaceutical since the landmark white paper published in 2011 by a National …
the pharmaceutical since the landmark white paper published in 2011 by a National …
A quantitative systems pharmacology perspective on the importance of parameter identifiability
There is an inherent tension in Quantitative Systems Pharmacology (QSP) between the
need to incorporate mathematical descriptions of complex physiology and drug targets with …
need to incorporate mathematical descriptions of complex physiology and drug targets with …
Evaluation framework for systems models
As decisions in drug development increasingly rely on predictions from mechanistic systems
models, assessing the predictive capability of such models is becoming more important …
models, assessing the predictive capability of such models is becoming more important …
Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems …
L Cucurull‐Sanchez, MJ Chappell… - CPT …, 2019 - Wiley Online Library
The lack of standardization in the way that quantitative and systems pharmacology (QSP)
models are developed, tested, and documented hinders their reproducibility, reusability, and …
models are developed, tested, and documented hinders their reproducibility, reusability, and …
Optimizing antimicrobial therapy by integrating multi-omics with pharmacokinetic/pharmacodynamic models and precision dosing
In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant
(MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize …
(MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize …
A framework for simplification of quantitative systems pharmacology models in clinical pharmacology
Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and
simulation that has gained wide attention over the past few years. The application of QSP …
simulation that has gained wide attention over the past few years. The application of QSP …
Integration of heterogeneous biological data in multiscale mechanistic model calibration: application to lung adenocarcinoma
JL Palgen, A Perrillat-Mercerot, N Ceres, E Peyronnet… - Acta biotheoretica, 2022 - Springer
Mechanistic models are built using knowledge as the primary information source, with well-
established biological and physical laws determining the causal relationships within the …
established biological and physical laws determining the causal relationships within the …
Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic intervention
E Righetti, A Antonello, L Marchetti… - Frontiers in Applied …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, yet there is no disease-modifying therapy up to this date. The biological …
worldwide, yet there is no disease-modifying therapy up to this date. The biological …