Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis
Adrenal steroidogenesis has, for decades, been depicted as three biosynthesis pathways–
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …
Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21 …
Hydroxylase deficiency presents with increased levels of cytochrome P450 21‐hydroxylase
substrates, progesterone and 17α-hydroxyprogesterone, which have been implicated in the …
substrates, progesterone and 17α-hydroxyprogesterone, which have been implicated in the …
The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway
Abstract Increased circulating 11β-hydroxyprogesterone (11OHP4), biosynthesised in the
human adrenal, is associated with 21-hydroxylase deficiency in congenital adrenal …
human adrenal, is associated with 21-hydroxylase deficiency in congenital adrenal …
CYP17A1 exhibits 17αhydroxylase/17, 20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway
Abstract Cytochrome P450 17α-hydroxylase/17, 20-lyase (CYP17A1) plays a pivotal role in
the regulation of adrenal and gonadal steroid hormone biosynthesis. More recent studies …
the regulation of adrenal and gonadal steroid hormone biosynthesis. More recent studies …
Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2-MS/MS
BACKGROUND We recently identified 35 women with polycystic ovarian syndrome (PCOS)
who exhibited features of micronodular adrenocortical hyperplasia. Steroid hormone …
who exhibited features of micronodular adrenocortical hyperplasia. Steroid hormone …
[CITATION][C] Complex metabolism of the novel neurosteroid, ganaxolone, in humans: a unique challenge for metabolites in safety testing assessment
The metabolism of 11β-hydroxyandrostenedione by steroidogenic enzymes yields metabolites contributing to the androgen pool in prostate cancer
T Du Toit - 2018 - scholar.sun.ac.za
This study describes:• The development and validation of three ultra-performance
convergence chromatography tandem mass spectrometry (UPC2-MS/MS) analytical …
convergence chromatography tandem mass spectrometry (UPC2-MS/MS) analytical …