[HTML][HTML] Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease

Z Zhou, Y Yan, H Gu, R Sun, Z Liao… - Neural regeneration …, 2024 - journals.lww.com
Parkinson's disease can affect not only motor functions but also cognitive abilities, leading to
cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction …

Turning touch into perception

R Romo, R Rossi-Pool - Neuron, 2020 - cell.com
Many brain areas modulate their activity during vibrotactile tasks. The activity from these
areas may code the stimulus parameters, stimulus perception, or perceptual reports. Here …

Sexually dimorphic dopaminergic circuits determine sex preference

A Wei, A Zhao, C Zheng, N Dong, X Cheng, X Duan… - Science, 2025 - science.org
Sociosexual preference is critical for reproduction and survival. However, neural
mechanisms encoding social decisions on sex preference remain unclear. In this study, we …

[HTML][HTML] Adolescent neurodevelopment and psychopathology: The interplay between adversity exposure and genetic risk for accelerated brain ageing

R Petrican, A Fornito - Developmental cognitive neuroscience, 2023 - Elsevier
In adulthood, stress exposure and genetic risk heighten psychological vulnerability by
accelerating neurobiological senescence. To investigate whether molecular and brain …

Emergent perceptual biases from state-space geometry in trained spiking recurrent neural networks

L Serrano-Fernández, M Beirán, N Parga - Cell Reports, 2024 - cell.com
A stimulus held in working memory is perceived as contracted toward the average stimulus.
This contraction bias has been extensively studied in psychophysics, but little is known …

Cortical VIP neurons as a critical node for dopamine actions

JW Bae, JH Yi, SY Choe, Y Li, MW Jung - Science Advances, 2025 - science.org
Dopamine modulates a wide range of cognitive processes in the prefrontal cortex, but the
underlying mechanisms remain unclear. Here, we examined the roles of prefrontal …

Emergent computations in trained artificial neural networks and real brains

N Parga, L Serrano-Fernández… - Journal of …, 2023 - iopscience.iop.org
Synaptic plasticity allows cortical circuits to learn new tasks and to adapt to changing
environments. How do cortical circuits use plasticity to acquire functions such as decision …

Rigid reduced successor representation as a potential mechanism for addiction

K Shimomura, A Kato, K Morita - European Journal of …, 2021 - Wiley Online Library
Difficulty in cessation of drinking, smoking, or gambling has been widely recognized.
Conventional theories proposed relative dominance of habitual over goal‐directed control …

[HTML][HTML] Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players

EC Latagliata, C Orsini, S Cabib, F Biagioni, F Fornai… - Biomedicines, 2023 - mdpi.com
Deficits in cognitive flexibility have been characterized in affective, anxiety, and
neurodegenerative disorders. This paper reviews data, mainly from studies on animal …

Representation of a perceptual bias in the prefrontal cortex

L Serrano-Fernández, M Beirán, R Romo… - Proceedings of the …, 2024 - pnas.org
Perception is influenced by sensory stimulation, prior knowledge, and contextual cues,
which collectively contribute to the emergence of perceptual biases. However, the precise …