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[HTML][HTML] Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease
Z Zhou, Y Yan, H Gu, R Sun, Z Liao… - Neural regeneration …, 2024 - journals.lww.com
Parkinson's disease can affect not only motor functions but also cognitive abilities, leading to
cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction …
cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction …
Turning touch into perception
Many brain areas modulate their activity during vibrotactile tasks. The activity from these
areas may code the stimulus parameters, stimulus perception, or perceptual reports. Here …
areas may code the stimulus parameters, stimulus perception, or perceptual reports. Here …
Sexually dimorphic dopaminergic circuits determine sex preference
A Wei, A Zhao, C Zheng, N Dong, X Cheng, X Duan… - Science, 2025 - science.org
Sociosexual preference is critical for reproduction and survival. However, neural
mechanisms encoding social decisions on sex preference remain unclear. In this study, we …
mechanisms encoding social decisions on sex preference remain unclear. In this study, we …
[HTML][HTML] Adolescent neurodevelopment and psychopathology: The interplay between adversity exposure and genetic risk for accelerated brain ageing
In adulthood, stress exposure and genetic risk heighten psychological vulnerability by
accelerating neurobiological senescence. To investigate whether molecular and brain …
accelerating neurobiological senescence. To investigate whether molecular and brain …
Emergent perceptual biases from state-space geometry in trained spiking recurrent neural networks
L Serrano-Fernández, M Beirán, N Parga - Cell Reports, 2024 - cell.com
A stimulus held in working memory is perceived as contracted toward the average stimulus.
This contraction bias has been extensively studied in psychophysics, but little is known …
This contraction bias has been extensively studied in psychophysics, but little is known …
Cortical VIP neurons as a critical node for dopamine actions
Dopamine modulates a wide range of cognitive processes in the prefrontal cortex, but the
underlying mechanisms remain unclear. Here, we examined the roles of prefrontal …
underlying mechanisms remain unclear. Here, we examined the roles of prefrontal …
Emergent computations in trained artificial neural networks and real brains
N Parga, L Serrano-Fernández… - Journal of …, 2023 - iopscience.iop.org
Synaptic plasticity allows cortical circuits to learn new tasks and to adapt to changing
environments. How do cortical circuits use plasticity to acquire functions such as decision …
environments. How do cortical circuits use plasticity to acquire functions such as decision …
Rigid reduced successor representation as a potential mechanism for addiction
Difficulty in cessation of drinking, smoking, or gambling has been widely recognized.
Conventional theories proposed relative dominance of habitual over goal‐directed control …
Conventional theories proposed relative dominance of habitual over goal‐directed control …
[HTML][HTML] Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players
Deficits in cognitive flexibility have been characterized in affective, anxiety, and
neurodegenerative disorders. This paper reviews data, mainly from studies on animal …
neurodegenerative disorders. This paper reviews data, mainly from studies on animal …
Representation of a perceptual bias in the prefrontal cortex
Perception is influenced by sensory stimulation, prior knowledge, and contextual cues,
which collectively contribute to the emergence of perceptual biases. However, the precise …
which collectively contribute to the emergence of perceptual biases. However, the precise …