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Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Z Fu, S Li, S Han, C Shi, Y Zhang - Signal transduction and targeted …, 2022 - nature.com
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs)
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …
The unique properties of IgG4 and its roles in health and disease
IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …
[HTML][HTML] A comprehensive review of key factors affecting the efficacy of antibody drug conjugate
Abstract Antibody Drug Conjugate (ADC) is an emerging technology to overcome the
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …
[HTML][HTML] Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers
MH Shamji, SR Durham - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and
asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical …
asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical …
IgG subclasses and allotypes: from structure to effector functions
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper
Background Allergen immunotherapy (AIT) is an effective treatment for allergic
rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex …
rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex …
IgG4-related disease
JH Stone, Y Zen, V Deshpande - New England Journal of …, 2012 - Mass Medical Soc
IgG4-Related Disease | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
AF Labrijn, JI Meesters, BECG de Goeij… - Proceedings of the …, 2013 - pnas.org
The promise of bispecific antibodies (bsAbs) to yield more effective therapeutics is well
recognized; however, the generation of bsAbs in a practical and cost-effective manner has …
recognized; however, the generation of bsAbs in a practical and cost-effective manner has …
IgG4-related disease
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated condition that
can affect almost any organ and is now being recognized with increasing frequency. IgG4 …
can affect almost any organ and is now being recognized with increasing frequency. IgG4 …
Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: a randomized controlled trial
Background Thymic stromal lymphopoietin (TSLP) has been shown to play a central role in
the initiation and persistence of allergic responses. Objective We evaluated whether …
the initiation and persistence of allergic responses. Objective We evaluated whether …