[HTML][HTML] Fold-change detection in biological systems

M Adler, U Alon - Current Opinion in Systems Biology, 2018 - Elsevier
Many sensory systems in cells and organisms share a recurring property called fold-change
detection (FCD). FCD describes a system whose dynamics–including amplitude and …

[HTML][HTML] Optimal regulatory circuit topologies for fold-change detection

M Adler, P Szekely, A Mayo, U Alon - Cell systems, 2017 - cell.com
Evolution repeatedly converges on only a few regulatory circuit designs that achieve a given
function. This simplicity helps us understand biological networks. However, why so few …

An adaptive-threshold mechanism for odor sensation and animal navigation

S Levy, CI Bargmann - Neuron, 2020 - cell.com
Identifying the environmental information and computations that drive sensory detection is
key for understanding animal behavior. Using experimental and theoretical analysis of AWC …

Logarithmic and power law input-output relations in sensory systems with fold-change detection

M Adler, A Mayo, U Alon - PLoS computational biology, 2014 - journals.plos.org
Two central biophysical laws describe sensory responses to input signals. One is a
logarithmic relationship between input and output, and the other is a power law relationship …

Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis

SW Lee, Y Morishita - PLoS Computational Biology, 2017 - journals.plos.org
Cell competition is a phenomenon originally described as the competition between cell
populations with different genetic backgrounds; losing cells with lower fitness are eliminated …

Fold change detection in visual processing

C Borba, MJ Kourakis, S Schwennicke… - Frontiers in Neural …, 2021 - frontiersin.org
Visual processing transforms the complexities of the visual world into useful information.
Ciona, an invertebrate chordate and close relative of the vertebrates, has one of the simplest …

[HTML][HTML] Canalization-based vein formation in a growing leaf

SW Lee, FG Feugier, Y Morishita - Journal of theoretical biology, 2014 - Elsevier
Vein formation is an important process in plant leaf development. The phytohormone auxin
is known as the most important molecule for the control of venation patterning; and the …

Comparison of adaptation motifs: temporal, stochastic and spatial responses

PA Iglesias, C Shi - IET systems biology, 2014 - Wiley Online Library
The cells' ability to adapt to changes in the external environment is crucial for the survival of
many organisms. There are two broad classes of signalling networks that achieve perfect …

Reducing Echo Chamber Effects: An Allostatic Regulator for Recommendation Algorithms

N Henry, M Pedersen, M Williams, J Martin, L Donkin - 2023 - researchsquare.com
Recommendation systems are prevalent on the Internet but are prone to feedback loops that
cause 'echo chamber'effects. We present an allostatic regulator for recommendation systems …

Two types of critical cell density for mechanical elimination of abnormal cell clusters from epithelial tissue

SW Lee, Y Morishita - PLOS Computational Biology, 2022 - journals.plos.org
Recent technological advances in high-resolution imaging and artificial modulation of
genetic functions at different times and regions have enabled direct observations of the …