Adding a cationic helper lipid to a lipid nanoparticle (LNP) can increase lung delivery and
decrease liver delivery. However, it remains unclear whether charge-dependent tropism is …

Clinically relevant immunological biomarkers that discriminate between diverse
hypofunctional states of tumor-associated CD8+ T cells remain disputed. Using multiomics …

Lipid nanoparticles (LNPs) have delivered RNA to hepatocytes in patients, underscoring the
potential impact of nonliver delivery. Scientists can shift LNP tropism to the lung by adding …

In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have
largely been explored in the context of pain, nerve injury, and repair. However, we …

Major histocompatibility complex class II (MHC-II) is the most significant genetic risk factor for
systemic lupus erythematosus (SLE), but the nature of the self-antigens that trigger …

Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy
against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear …

Transplantation of ex vivo engineered hematopoietic stem cells (HSCs) can lead to robust
clinical responses but carries risks of adverse events from bone marrow mobilization …

Gaucher disease (GD) is the most common lysosomal storage disease caused by recessive
mutations in the degrading enzyme of β-glucosylceramide (β-GlcCer). However, it remains …

Current protocols for producing cerebellar neurons from human pluripotent stem cells
(hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their …

Aging is a strong risk factor for atherosclerosis and induces accumulation of memory CD8+ T
cells in mice and humans. Biological changes that occur with aging lead to enhanced …