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Diltiazem: a review of its pharmacological properties and therapeutic efficacy
M Chaffman, RN Brogden - Drugs, 1985 - Springer
Diltiazem 1 is an orally and intravenously active calcium channel blocking agent shown to
be an effective and well-tolerated treatment for stable angina and angina due to coronary …
be an effective and well-tolerated treatment for stable angina and angina due to coronary …
Calcium antagonists
E Grossman, FH Messerli - Progress in Cardiovascular Diseases, 2004 - Elsevier
Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their
use was subsequently expanded to additional disorders, such as angina pectoris …
use was subsequently expanded to additional disorders, such as angina pectoris …
Late sodium current block for drug‐induced long QT syndrome: results from a prospective clinical trial
Drug‐induced long QT syndrome has resulted in many drugs being withdrawn from the
market. At the same time, the current regulatory paradigm for screening new drugs causing …
market. At the same time, the current regulatory paradigm for screening new drugs causing …
Ventricular control and exercise performance in chronic atrial fibrillation: Effects of diltiazem verapamil
T Lundström, L Rydén - Journal of the American College of Cardiology, 1990 - Elsevier
The effects of two calcium channel blockers, diltiazem (270 mg/day) and verapamil (240
mg/day), were studied in 18 patients with chronic atrial fibrillation. During 24 h Holter …
mg/day), were studied in 18 patients with chronic atrial fibrillation. During 24 h Holter …
Pharmacological activation of KCa3. 1/KCa2. 3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs
M Damkjaer, G Nielsen, S Bodendiek… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE In rodents, the endothelial KCa channels, KCa3. 1 and
KCa2. 3, have been shown to play a crucial role in initiating endothelium‐derived …
KCa2. 3, have been shown to play a crucial role in initiating endothelium‐derived …
The use of a calcium‐channel blocker, nicardipine, for severely asphyxiated newborn infants
MI Levene, NA Gibson, AC Fenton… - … Medicine & Child …, 1990 - Wiley Online Library
SUMMARY A continuous infusion of nicardipine was given to four severely asphyxiated
fullterm infants who were at high risk for adverse outcome and had abnormal cerebral …
fullterm infants who were at high risk for adverse outcome and had abnormal cerebral …
Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant
T Matsubara, T Bohgaki, M Watarai… - Biological and …, 1999 - jstage.jst.go.jp
MATERIALS AND METHODS Animals Male Wistar rats weighing 250—300g (Japan SLC,
Inc., Hamamatsu) and male Hartley guinea pigs weigh—ing about 400 g (Japan SLC, Inc …
Inc., Hamamatsu) and male Hartley guinea pigs weigh—ing about 400 g (Japan SLC, Inc …
Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients: altered electrocardiographic and hypotensive responses
DR ABERNETHY, JB SCHWARTZ… - Annals of internal …, 1986 - acpjournals.org
We studied verapamil pharmacodynamics and disposition in seven young, ten elderly, and
seven very elderly hypertensive males. Maximal decrease in mean (±SD) blood pressure …
seven very elderly hypertensive males. Maximal decrease in mean (±SD) blood pressure …
Cellular action of calcium channel blocking drugs.
A Schwartz, DJ Triggle - Annual review of medicine, 1984 - europepmc.org
The calcium antagonists are an exciting" class" of drugs that are already making an
important impact in the treatment of coronary artery disease. All three drugs in use in the US …
important impact in the treatment of coronary artery disease. All three drugs in use in the US …
The pharmacological basis and pathophysiological significance of the heart rate‐lowering property of diltiazem
SE O'Connor, A Grosset… - Fundamental & clinical …, 1999 - Wiley Online Library
The calcium channel blocker diltiazem lowers heart rate in man and this property probably
contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This …
contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This …