Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …

This paper gives an overview of the recent advances in engineering the central carbon
metabolism of the industrially important bacteria Escherichia coli, Bacillus subtilis …

Members of the genus Streptomyces are mycelial bacteria that undergo a complex
multicellular life cycle and propagate via sporulation. Streptomycetes are important industrial …

Actinomycetes are Gram-positive bacteria showing a filamentous growth. They are a group
of organisms widespread in nature, and play a significant role in the future of biotechnology …

Metabolic engineering is a powerful tool for the optimisation and the introduction of new
cellular processes. This is mostly done by genetic engineering. Since the introduction of this …

A stoichiometric model of central metabolism was developed based on new information
regarding metabolism in this bacterium to evaluate the steady‐state growth capabilities of …

ABSTRACT Glucose-6-phosphate dehydrogenase (G6PDH) is widely distributed in nature
and catalyzes the first committing step in the oxidative branch of the pentose phosphate (PP) …

The study of a collection of metabolites as a whole (metabolome), as opposed to isolated
small molecules, is a fast‐growing field promising to take us one step further towards …

Streptomycetes are Gram-positive, soil-inhabiting bacteria of the order Actinomycetales.
These organisms exhibit an unusual, developmentally complex life cycle and produce many …

Microbial secondary metabolites are intensively explored due to their demands in
pharmaceutical, agricultural and food industries. Streptomyces are one of the largest …