Insulin synthesis in pancreatic β‐cells is initiated as preproinsulin. Prevailing glucose
concentrations, which oscillate pre‐and postprandially, exert major dynamic variation in …

Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …

Directed differentiation of human pluripotent stem cells into functional insulin‐producing
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …

Insulin plays a central role in the regulation of human metabolism. The hormone is a 51-
residue anabolic protein that is secreted by the β-cells in the Islets of Langerhans …

To maintain copious insulin granule stores in the face of ongoing metabolic demand,
pancreatic beta cells must produce large quantities of proinsulin, the insulin precursor …

Biosynthesis of insulin–critical to metabolic homeostasis–begins with folding of the
proinsulin precursor, including formation of three evolutionarily conserved intramolecular …

Pancreatic β-cells are prone to endoplasmic reticulum (ER) stress due to their role in insulin
secretion. They require sustainable and efficient adaptive stress responses to cope with this …

A growing list of insulin gene mutations causing a new form of monogenic diabetes has
drawn increasing attention over the past seven years. The mutations have been identified in …

The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the
COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor …

Abstract The reticulon-3 (RTN3)-driven targeting complex promotes clearance of misfolded
prohormones from the endoplasmic reticulum (ER) for lysosomal destruction by ER-phagy …