The Alzheimer's disease mitochondrial cascade hypothesis
We first proposed the mitochondrial cascade hypothesis of sporadic Alzheimer's disease
(AD) in 2004. Our core assumptions were a person's genes determine baseline …
(AD) in 2004. Our core assumptions were a person's genes determine baseline …
What did you do yesterday? A meta-analysis of sex differences in episodic memory.
To remember what one did yesterday is an example of an everyday episodic memory task,
in which a female advantage has sometimes been reported. Here, we quantify the impact of …
in which a female advantage has sometimes been reported. Here, we quantify the impact of …
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations
Brain imaging can be used to study how individuals' brains are aging, compared against
population norms. This can inform on aspects of brain health; for example, smoking and …
population norms. This can inform on aspects of brain health; for example, smoking and …
[HTML][HTML] Is Alzheimer's disease a systemic disease?
Although Alzheimer's disease (AD) is the most common neurodegenerative disease, the
etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a …
etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a …
Bone-to-brain: a round trip in the adaptation to mechanical stimuli
L Gerosa, G Lombardi - Frontiers in Physiology, 2021 - frontiersin.org
Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …
Metabolic and non-cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology
M Ishii, C Iadecola - Cell metabolism, 2015 - cell.com
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …
Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease, and numerous
recent findings suggest that several pathologic signs, including loss of muscle strength and …
recent findings suggest that several pathologic signs, including loss of muscle strength and …
Effects of neurological disorders on bone health
RR Kelly, SJ Sidles, AC LaRue - Frontiers in psychology, 2020 - frontiersin.org
Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …
life and can negatively affect bone health. The brain-bone axis is critically important for …
Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer's disease-induced estrogen deficient rats
BK Shin, S Kang, DS Kim… - Experimental biology and …, 2018 - journals.sagepub.com
Intermittent fasting may be an effective intervention to protect against age-related metabolic
disturbances, although it is still controversial. Here, we investigated the effect of intermittent …
disturbances, although it is still controversial. Here, we investigated the effect of intermittent …
Effects of a primary care-based multifactorial intervention on physical and cognitive function in frail, elderly individuals: a randomized controlled trial
L Romera-Liebana, F Orfila, JM Segura… - The Journals of …, 2018 - academic.oup.com
Background Detecting and managing frailty at early stages can prevent disability and other
adverse outcomes. The study aim was to evaluate whether a multifactorial intervention …
adverse outcomes. The study aim was to evaluate whether a multifactorial intervention …