Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Per-ARNT-Sim (PAS) domains serve as versatile sensor and interaction modules in signal
transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the …

The discovery of light-inducible protein–protein interactions has allowed for the spatial and
temporal control of a variety of biological processes. To be effective, a photodimerizer …

The precise spatio-temporal dynamics of protein activity are often critical in determining cell
behaviour, yet for most proteins they remain poorly understood; it remains difficult to …

Naturally photoswitchable proteins offer a means of directly manipulating the formation of
protein complexes that drive a diversity of cellular processes. We developed tunable light …

Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-
order levels, an organization that guides our current understanding of their biological …

Signaling photoreceptors use the information contained in the absorption of a photon to
modulate biological activity in plants and a wide range of organisms. The fundamental—and …

Optogenetic and chemogenetic control of proteins has revealed otherwise inaccessible
facets of signaling dynamics. Here, we use light-or ligand-sensitive domains to modulate the …

Recent work indicates a general architecture for proteins in which sparse networks of
physically contiguous and coevolving amino acids underlie basic aspects of structure and …

The Light-Oxygen-Voltage domain family of proteins is widespread in biology where they
impart sensory responses to signal transduction domains. The small, light responsive LOV …