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Frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …
dementia and presents with early social–emotional–behavioural and/or language changes …
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum
Importance Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that
increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease …
increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease …
LATE-NC staging in routine neuropathologic diagnosis: an update
An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
The second NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with
exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB …
exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB …
Molecular characterization of selectively vulnerable neurons in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …
populations, the molecular signatures of which are largely unknown. To identify and …
Clinical neurology and epidemiology of the major neurodegenerative diseases
MG Erkkinen, MO Kim… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …
older adults. Most clinicians who care for the elderly are not trained to diagnose these …
Tau kinetics in neurons and the human central nervous system
We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …
kinetics of multiple isoforms and fragments of tau in the human central nervous system …
Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) share
many clinical, pathological, and genetic features, but a detailed understanding of their …
many clinical, pathological, and genetic features, but a detailed understanding of their …
Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football
Importance Players of American football may be at increased risk of long-term neurological
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …