Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

The ability of a eukaryotic cell to resist deformation, to transport intracellular cargo and to
change shape during movement depends on the cytoskeleton, an interconnected network of …

Cell migration is a highly integrated multistep process that orchestrates embryonic
morphogenesis; contributes to tissue repair and regeneration; and drives disease …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory
proteins—is the primary force-generating machinery in the cell. It can produce pushing …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …

The protein actin forms filaments that provide cells with mechanical support and driving
forces for movement. Actin contributes to biological processes such as sensing …