Primary aldosteronism is a common cause of secondary hypertension associated with
excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it …

Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …

Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality
rates than essential hypertension. The Japan Endocrine Society (JES) has developed an …

Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Context New approaches are needed to address the evolution of the primary aldosteronism
syndrome and to increase its recognition. Herein, we review evidence indicating that primary …

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …