The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …

Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs) are
under investigation for their suitability as human models in preclinical drug development …

Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
have emerged as a promising experimental tool for translational heart research and drug …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

Maintenance of normal cardiac rhythm requires coordinated activity of ion channels and
transporters that allow well-ordered propagation of electrical impulses across the …

During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Background: Electrical remodeling in human persistent atrial fibrillation is believed to result
from rapid electrical activation of the atria, but underlying genetic causes may contribute …

In the heart, electrophysiological dysregulation arises from defects at many biological levels
(from point mutations in ion channel proteins to gross structural abnormalities). These …

The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …