Lipogenesis inhibitors: therapeutic opportunities and challenges
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
The functional roles of TCA cycle metabolites in cancer
The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for
generating cellular energy and precursors for biosynthetic pathways. Several cancers …
generating cellular energy and precursors for biosynthetic pathways. Several cancers …
Understanding global feature contributions with additive importance measures
Understanding the inner workings of complex machine learning models is a long-standing
problem and most recent research has focused on local interpretability. To assess the role of …
problem and most recent research has focused on local interpretability. To assess the role of …
Regulation of glucose and lipid metabolism in health and disease
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …
most abundant sterol in mammals, is a key component of cell membranes although it does …
[HTML][HTML] The role of lipid metabolic reprogramming in tumor microenvironment
K Yang, X Wang, C Song, Z He, R Wang, Y Xu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …
Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
Metabolic reprograming mediated by tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPα blockade efficacy
H Zhou, W Wang, H Xu, Y Liang, J Ding, M Lv… - Nature …, 2024 - nature.com
Type I interferons have been well recognized for their roles in various types of immune cells
during tumor immunotherapy. However, their direct effects on tumor cells are less …
during tumor immunotherapy. However, their direct effects on tumor cells are less …
Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses
To uncover underlying mechanisms associated with failure of indoleamine 2, 3-dioxygenase
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study …
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study …
Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation
Y Li, YC Li, XT Liu, L Zhang, YH Chen, Q Zhao, W Gao… - Cell reports, 2022 - cell.com
The metabolism of activated macrophages relies on aerobic glycolysis, while mitochondrial
oxidation is disrupted. In lipopolysaccharide-activated macrophages, the citrate carrier (CIC) …
oxidation is disrupted. In lipopolysaccharide-activated macrophages, the citrate carrier (CIC) …
[HTML][HTML] Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy
D Liu, Y Hong, Y Li, C Hu, TC Yip, WK Yu, Y Zhu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy
resistance. Therefore, a CSC-targeted therapy that disrupts the maintenance and survival of …
resistance. Therefore, a CSC-targeted therapy that disrupts the maintenance and survival of …