The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Over more than a century of research has established the fact that sleep benefits the
retention of memory. In this review we aim to comprehensively cover the field of “sleep and …

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

Sleep remains a major mystery of biology. In particular, little is known about the mechanisms
that account for the drive to sleep. In an unbiased screen of more than 12,000 Drosophila …

Sleep remains one of the least understood phenomena in biology—even its role in synaptic
plasticity remains debatable. Since sleep was recognized to be regulated genetically …

Despite decades of intense study, the functions of sleep are still shrouded in mystery. The
difficulty in understanding these functions can be at least partly attributed to the varied …

Background The neuronal circuitry underlying sleep is poorly understood. Although
dopamine (DA) is thought to play a key role in sleep/wake regulation, the identities of the …

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …