Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - Signal transduction and …, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Biomarkers of oxidative stress in metabolic syndrome and associated diseases

R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …

Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy

NJ Byrne, NS Rajasekaran, ED Abel… - Free Radical Biology and …, 2021 - Elsevier
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling

L Schirone, M Forte, S Palmerio, D Yee… - Oxidative medicine …, 2017 - Wiley Online Library
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities

I Russo, NG Frangogiannis - Journal of molecular and cellular cardiology, 2016 - Elsevier
Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …

Diabetic cardiovascular disease induced by oxidative stress

Y Kayama, U Raaz, A Jagger, M Adam… - International journal of …, 2015 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among
patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications …

Redox signaling in diabetic wound healing regulates extracellular matrix deposition

B Kunkemoeller, TR Kyriakides - Antioxidants & redox signaling, 2017 - liebertpub.com
Significance: Impaired wound healing is a major complication of diabetes, and can lead to
development of chronic foot ulcers in a significant number of patients. Despite the danger …

[HTML][HTML] Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

ZV Varga, Z Giricz, L Liaudet, G Haskó… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment

I Falcão-Pires, AF Leite-Moreira - Heart failure reviews, 2012 - Springer
Diabetes mellitus is an important and prevalent risk factor for congestive heart failure.
Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic …

Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4 …

Z Zhu, Y Liu, Y Gong, W **, E Topchiy… - Acta Pharmacologica …, 2022 - nature.com
Alzheimer's disease (AD) is associated with high incidence of cardiovascular events but the
mechanism remains elusive. Our previous study reveals a tight correlation between cardiac …