We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

1. Introduction 3082. Plan of this article 3123. Natural mechanisms of development of novel
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …

Predicting the function of a protein from its amino acid sequence is a long-standing
challenge in bioinformatics. Traditional approaches use sequence alignment to compare a …

Abstract InterPro (http://www. ebi. ac. uk/interpro/) is a database that integrates diverse
information about protein families, domains and functional sites, and makes it freely …

To provide the scientific community with a single, centralized, authoritative resource for
protein sequences and functional information, the Swiss‐Prot, TrEMBL and PIR protein …

Abstract InterProScan [EM Zdobnov and R. Apweiler (2001) Bioinformatics, 17, 847–848] is
a tool that combines different protein signature recognition methods from the InterPro [NJ …

Abstract The InterPro database (http://www. ebi. ac. uk/interpro/) integrates together
predictive models or 'signatures' representing protein domains, families and functional sites …

Motivation: As improved DNA sequencing techniques have increased enormously the speed
of producing new eukaryotic genome assemblies, the further development of automated …

Abstract The Universal Protein Resource (UniProt) provides the scientific community with a
single, centralized, authoritative resource for protein sequences and functional information …

Due to the rapid release of new data from genome sequencing projects, the majority of
protein sequences in public databases have not been experimentally characterized; rather …