[HTML][HTML] Obesity management in the primary prevention of hepatocellular carcinoma

ERM Zunica, EC Heintz, CL Axelrod, JP Kirwan - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an increasingly prevalent and deadly
disease driven in part by the rising obesity epidemic. Obesity causes HCC by initiating and …

Revisiting the concepts of de novo lipogenesis to understand the conversion of carbohydrates into fats: stop overvaluing and extrapolating the renowned phrase" fat …

HO Santos, N Penha-Silva - Nutrition, 2024 - Elsevier
Carbohydrates can be converted into fatty acids via de novo lipogenesis (DNL). Although
DNL is considered inefficient, these endogenous fatty acids contribute substantially to the …

[HTML][HTML] Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: The TANGO randomized controlled trial

YC Chooi, QA Zhang, F Magkos, M Ng… - The American Journal of …, 2024 - Elsevier
Background Weight loss is the most effective treatment for nonalcoholic fatty liver disease
(NAFLD). There is evidence that the Mediterranean diets rich in unsaturated fatty acids and …

[HTML][HTML] Reduction of De Novo lipogenesis mediates beneficial effects of isoenergetic diets on fatty liver: mechanistic insights from the MEDEA randomized clinical trial

G Costabile, G Della Pepa, D Salamone, D Luongo… - Nutrients, 2022 - mdpi.com
Background: Non-alcoholic liver steatosis (NAS) results from an imbalance between hepatic
lipid storage, disposal, and partitioning. A multifactorial diet high in fiber, monounsaturated …

[HTML][HTML] Lipid metabolism in MASLD and MASH: From mechanism to the clinic

F Carli, G Della Pepa, S Sabatini, AV Puig… - JHEP Reports, 2024 - Elsevier
Abstract Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD) is recognized
as a metabolic disease characterized by excess intrahepatic lipid accumulation due to lipid …

Carbohydrates deteriorate fatty liver by activating the inflammatory response

Y Gao, R Hua, K Hu, Z Wang - Nutrition research reviews, 2022 - cambridge.org
Non-alcoholic fatty liver disease (NAFLD) was defined in 1980 and has the same
histological characteristics as alcoholic liver disease except for alcohol consumption. After …

An isoenergetic multifactorial diet reduces pancreatic fat and increases postprandial insulin response in patients with type 2 diabetes: a randomized controlled trial

G Della Pepa, V Brancato, G Costabile… - Diabetes …, 2022 - diabetesjournals.org
OBJECTIVE To compare the effect of an isocaloric multifactorial diet with a diet rich in
monounsaturated fatty acids (MUFA) and similar macronutrient composition on pancreatic …

Intrapancreatic fat deposition and nutritional treatment: the role of various dietary approaches

G Della Pepa, D Salamone, R Testa… - Nutrition …, 2024 - academic.oup.com
Ectopic fat accumulation in various organs and tissues, such as the liver, muscle, kidney,
heart, and pancreas, is related to impaired capacity of adipose tissue to accumulate …

Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals

D Salamone, G Costabile, A Corrado, G Della Pepa… - Acta Diabetologica, 2022 - Springer
Aim aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in
patients with Type 2 diabetes (T2D) and overweight/obese individuals. Methods In forty …

[HTML][HTML] Diet quality, cardiometabolic risk and diabetes

G Della Pepa - Nutrients, 2023 - mdpi.com
The alarming rise in obesity worldwide is a dramatic public health concern [1], and changes
in lifestyle factors, such as low physical activity and the progressive diffusion of the high …