Bisphosphonates, used for a long time in osteoporosis management, are currently the target
of intensive research, from pre-formulation studies to more advanced stages of clinical …

Osteoporosis is an asymptomatic progressive disease. With the improvement of people's
living standard and the aging of population, osteoporosis and its fracture have become one …

Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …

Recent progress in the synthesis of major constituents of the methyl-1, 1-bisphosphonate
family is reviewed. These compounds are important precursors of the corresponding …

The aim of this article is to present an overview of new and useful silicon-based
methodologies valuable for the selective construction of highly functionalized mono-and …

Several synthetic pathways for obtaining phosphonic esters of the amino bisphosphonic
acids (NBPs) pamidronate, alendronate and neridronate were investigated. The general …

Bisphosphonates are well established pharmaceutical drugs with wide applications in
medicine. Nevertheless, the side chain and the nature of phosphorous groups could induce …

We investigated the biological effects of new synthesized bisphosphonates (BPs) on HuH7
hepatocarcinoma cells. BPs containing p-bromophenyl (R 1= p-Br, Ph, 2) in their side chain …

A practical generalisable procedure to synthesize hydroxymethylene H-bisphosphinates has
been optimised. Unlike previous reports, numerous alkyl (including an alendronate …

Phosphonates and their derivatives widely represent important pharmacophores in various
classes of therapeutic agents from antivirals to antibiotics. Among these phosphonylated …