Mitochondrial DNA variation and cancer
Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …
Revising the human mutation rate: implications for understanding human evolution
It is now possible to make direct measurements of the mutation rate in modern humans
using next-generation sequencing. These measurements reveal a value that is …
using next-generation sequencing. These measurements reveal a value that is …
Genomic insights into the formation of human populations in East Asia
The deep population history of East Asia remains poorly understood owing to a lack of
ancient DNA data and sparse sampling of present-day people,. Here we report genome …
ancient DNA data and sparse sampling of present-day people,. Here we report genome …
Large-scale migration into Britain during the Middle to Late Bronze Age
Present-day people from England and Wales have more ancestry derived from early
European farmers (EEF) than did people of the Early Bronze Age 1. To understand this, here …
European farmers (EEF) than did people of the Early Bronze Age 1. To understand this, here …
The genetic history of the Southern Arc: A bridge between West Asia and Europe
By sequencing 727 ancient individuals from the Southern Arc (Anatolia and its neighbors in
Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic …
Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic …
The genomic history of the Iberian Peninsula over the past 8000 years
We assembled genome-wide data from 271 ancient Iberians, of whom 176 are from the
largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect …
largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect …
The Beaker phenomenon and the genomic transformation of northwest Europe
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and
central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled …
central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled …
Genomic insights into the origin of farming in the ancient Near East
We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time
between~ 12,000 and 1,400 bc, from Natufian hunter–gatherers to Bronze Age farmers. We …
between~ 12,000 and 1,400 bc, from Natufian hunter–gatherers to Bronze Age farmers. We …
Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago
Southern Africa is consistently placed as a potential region for the evolution of Homo
sapiens. We present genome sequences, up to 13x coverage, from seven ancient …
sapiens. We present genome sequences, up to 13x coverage, from seven ancient …
HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing
H Weissensteiner, D Pacher… - Nucleic acids …, 2016 - academic.oup.com
Mitochondrial DNA (mtDNA) profiles can be classified into phylogenetic clusters
(haplogroups), which is of great relevance for evolutionary, forensic and medical genetics …
(haplogroups), which is of great relevance for evolutionary, forensic and medical genetics …