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Cellular and molecular mechanisms of metformin action
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-
lowering effects, well-established safety profile, and relatively low cost. While metformin has …
lowering effects, well-established safety profile, and relatively low cost. While metformin has …
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS
Abstract GGGGCC (G 4 C 2) hexanucleotide repeat expansion in the C9ORF72 gene is the
most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral …
most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral …
[HTML][HTML] Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS
H Xu, C Jia, C Cheng, H Wu, H Cai, W Le - Free Radical Biology and …, 2022 - Elsevier
Abstract Mutations in Cu/Zn–superoxide dismutase 1 (SOD1) are linked to amyotrophic
lateral sclerosis (ALS). Using a line of ALS-related mutant human SOD1 (hSOD1) transgenic …
lateral sclerosis (ALS). Using a line of ALS-related mutant human SOD1 (hSOD1) transgenic …
Insulin and metformin are associated with reduced risk of amyotrophic lateral sclerosis
S Lehrer, PH Rheinstein - Chronic Diseases and Translational …, 2024 - Wiley Online Library
Abstract Background Type 2 diabetes (T2D), but not type 1, protected against amyotrophic
lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages. Type 1 …
lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages. Type 1 …
Utilising CRISPR-Cas13 systems to target C9orf72 repeat expansion-containing RNA
L Kempthorne - 2023 - discovery.ucl.ac.uk
The most common genetic cause of both frontotemporal dementia and amyotrophic lateral
sclerosis is a G4C2 hexanucleotide repeat expansion (HRE) in intron 1 of the C9orf72 gene …
sclerosis is a G4C2 hexanucleotide repeat expansion (HRE) in intron 1 of the C9orf72 gene …