The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease,
Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms …

First isolated from Cannabis in 1940 by Roger Adams, the structure of CBD was not
completely elucidated until 1963. Subsequent studies resulted in the pronouncement that …

Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …

Obesity is an energy‐rich condition associated with overnutrition, which impairs systemic
metabolic homeostasis and elicits stress. It also activates an inflammatory process in …

Neurodegenerative diseases are a growing health concern. The increasing incidences of
these disorders have a great impact on the patients' quality of life. Although the mechanisms …

Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …